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The Health Examiner

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Health · Liver Health · Investigation
Sponsored Feature 7 September 2026

Fatty Liver Is No Longer An Obstacle For Me!

ALT: 112 to 28. AST: 89 to 24. Back inside range without a prescription. Over 11,690 people have used Uvera to support their liver. Here is the full story.

Jaundice, a yellowing of the whites of the eyes, is one of the visible warning signs of advanced liver stress.
Jaundice, a yellowing of the whites of the eyes, is one of the visible warning signs of advanced liver stress.Photo: The Health Examiner

What to Know

What Gareth discovered, and what changed

  • Found out he had fatty liver at 49: ALT 112, AST 89, yellow in the whites of his eyes, bloating and tired all the time.
  • His dad died of liver cirrhosis at 52. He was told the same thing could happen to him in 5 to 10 years.
  • 6 months of doing everything he was told moved his ALT 9 points.
  • Found out that stopping what goes in and clearing what is already stored are 2 different jobs. He was only doing the first one.
  • Found a British formula built on milk thistle standardised to 80% silymarin, with inositol and L-methionine.
  • ALT 112 to 28. AST 89 to 24. Both back to normal, and a scan that came back clear.

The Wake-Up Call

I Saw It In The Mirror At Work

I saw it in the bathroom mirror at work. The whites of my eyes had gone a bit yellow. The bloating I had been ignoring for weeks suddenly felt like the smallest of my problems. I locked the door, sat down, and typed "yellow eyes liver disease" into my phone with my hands shaking.

I was 49. I was meant to be in the best years of my life, doing well at work and enjoying it. Instead I was hiding in an office toilet trying not to cry while my phone gave me one scary result after another.

And the worst part? This was not just about me anymore. A few days before, my 8 year old daughter had asked me why I would not play football with her like I used to. "Daddy's just tired," I said. But the look on her face stayed with me for weeks. Would I even be around to see her finish school? My dad died of liver cirrhosis at 52. Was I going the same way?

The Turning Point

The Blood Test Results Hit Me Like A Truck

AST 89. ALT 112.

"These liver enzyme levels are dangerously high," my doctor said. She did not try to make it sound better than it was. "You have fatty liver disease. If you do not make changes now, you could be looking at cirrhosis in 5 to 10 years."

I spent that night going down a dark hole, reading story after story from people in the same boat. Reddit, health forums, comment sections, still going at 2 in the morning. One man wrote about ignoring his fatty liver for years: "Started with fatigue and brain fog. Then my bloods came back AST 74, ALT 109, and I ignored that too. Kept ignoring it until my skin started turning yellow. Now I'm 45 with end stage cirrhosis and they have told me I'm not eligible for a transplant. Don't be me." Another one wrote about losing his dad to it.

"Fatty liver is a silent killer. He was only 50. Never even knew he was sick until it was too late."

I have spent 15 years as a journalist digging up the things the health industry would rather keep quiet. Drug company marketing. Supplement scams. The odd real breakthrough. So I threw myself into the research, except this time it was my own blood test on the table. I needed to know what was really going on inside my body. And that is when I found the thing that changed everything.

The Root Cause

The Shocking Truth About Your Liver

Your liver is the only toxic waste plant your body has. Everything you eat, drink, or take in through your skin ends up going through your liver to be cleaned and filtered.

But here is the problem. Just like a real waste plant, your liver can get overwhelmed if too much comes in too fast. When that happens it starts storing the extra toxins and fat, a bit like dumping the leftover rubbish in a storage yard out the back. Over time that storage yard gets bigger and bigger, and your liver has to work harder and harder.

That explained why so many people's stories followed the same pattern. Feeling fine for years while their liver quietly filled up, then hitting a wall when the storage yard could not take any more.

It also answered the question I could not shake. Why now? I had been eating pretty much the same way for 20 years. But the liver has no pain nerves of its own, so it does not complain. It just quietly works around the problem. Year after year it takes the desk lunches, the late nights, the extra stone, until the year it cannot. By the time you spot a sign of it in the mirror, that yard has usually been filling up for 10 years.

The other thing I kept running into: you do not have to drink. Doctors call it non-alcoholic fatty liver disease for a reason. Story after story started the same way. "I barely touch alcohol and my enzymes came back high." If your enzymes came back high and you barely drink, you are not a strange case. You are the normal one.

And here is what that number on your blood test actually is. ALT and AST are enzymes that live inside your liver cells. They only show up in your blood in big amounts when liver cells are damaged and leaking.

That is what the number is. It is not a score. It is a leak rate.

Left to right: a healthy liver, then progressive fat infiltration, inflammation and scarring. The organ gives no pain signal at any stage of that journey.
Left to right: a healthy liver, then progressive fat infiltration, inflammation and scarring. The organ gives no pain signal at any stage of that journey.Photo: The Health Examiner

The Problem With Standard Advice

In my years of looking into health stories I have talked to a lot of experts and a lot of patients. But this was different. The science on liver damage was clear. The answers people were being given were not. Most doctors just said lose weight and exercise. As if it were that simple.

Here is what I did not know until this year. For most people with early fatty liver, there is no pill your doctor can give you. There is no medicine for it. Think about that for a second. High blood pressure has pills. Diabetes has pills and injections. Your heart, your kidneys, your thyroid, they all have something you can take. The liver is the one organ where they hand you a leaflet. What you get is what I got. Lose weight, exercise, come back in 6 months for another blood test. You are handed a frightening diagnosis and sent home with homework.

The supplement industry was not much better. Walk into any chemist and what you get handed is a big liver complex with 2 dozen ingredients on the back of the tub. Milk thistle, dandelion, artichoke, beetroot, 15 vitamins and a few things you have never heard of. It looks brilliant. It looks like it must be doing more than a simple one.

Then you read the amounts. Every single one of them is in there at a sprinkle. Nowhere near what the research used for any of them. You are not taking 24 ingredients. You are taking 24 tiny bits of 24 ingredients, which adds up to nothing.

And you already know how this works, because you have done it yourself in your own kitchen.

2 paracetamol will shift a headache. Take a quarter of one and you do not get a quarter of the relief. You get none. Your headache does not care that you took a bit of something.

That is how doses work. Everything has a level it has to get past before anything happens at all, and below that level it does not do a smaller version of the job.

Under the line is not a weaker version of working. It is not working.

So 24 ingredients all sat under the line is not 24 small helps added together. It is 24 things doing nothing, on a label that looks impressive.

What did not work, for me and for most people I heard from

  • Big liver complex pills with dozens of ingredients. Every one of them underdosed. My numbers never moved.
  • Generic milk thistle from the chemist. No percentage printed anywhere on the tub. 8 weeks of it. Nothing.
  • Diet on its own. Keto for 6 weeks. Then low carb. Then the full Mediterranean thing, olive oil and oily fish and the rest of it. Sugar gone. Alcohol gone completely, not cut down, gone. It helped a bit. It was nowhere near enough to move the enzymes.
  • TUDCA. Not cheap either. It works on bile, and bile is the plumbing. It is not the yard.
  • NAC. An antioxidant. It helps protect liver cells, which is worth having. But protecting cells does not shift a single thing out of storage.
  • Berberine. Works on blood sugar. That is one more thing arriving at the gates. It does nothing about what is already stacked up out the back.
  • Liver cleanse teas and detox kits. No real change in my blood tests at all.
  • Generic multivitamins. Did nothing whatsoever for fatty liver.

And I want to be clear about this next part, because this is where most people reading will see themselves. I did not do it half way. I cooked from scratch for 6 months. I walked 40 minutes every evening, in the rain in February. I lost a stone and a half. I said no to a wedding, 2 work dinners and my brother-in-law's 50th.

I went back for the recheck really expecting good news. I remember being almost cheerful in the waiting room.

ALT 103. 9 points. 6 months of my life, and 9 points.

I sat in the car park afterwards and did not start the engine for a while.

Because here is what a number like that does to you. It does not just let you down. It takes away the reason. If you had been cheating, you could fix it by not cheating. If you had been lazy, you could fix it by trying harder. I had not cheated and I had not been lazy, and the number had barely moved. Which leaves you with only one thing to think.

Maybe this is just what my liver is now. That is the thought. That is the one that sits with you at four in the morning.

The Breakthrough

The Thing Nobody Had Told Me

About 5 weeks into reading properly, sat at my kitchen table at half 11 at night, I found the thing that had been missing from every talk I had ever had about my own liver.

Food and drink are deliveries. Fat already sat in your liver is not a delivery. It is a pile in the yard.

Stopping the inputs stops it getting worse. It does not, by itself, clear what is already sitting there. Those are 2 separate jobs, and I had spent 6 months doing one of them and expecting credit for both.

Go back to the waste plant. Everything I had done for 6 months was about what came in the gates. Less arriving, less to deal with, fewer new deliveries to the yard. All of it sensible. All of it needed.

None of it was about the yard.

Stopping the deliveries stops the pile growing. It does not move a single thing that is already stacked out there, because clearing the yard is a different job and it needs different tools.

A full storage yard does not empty itself just because you stopped adding to it.

That was the whole thing. That was my 6 months in one sentence. I had shut the gates. Nobody had said a word to me about clearing the yard.

So I Stopped Reading Blogs And Went To PubMed

PubMed is the free database where the actual medical studies live. It is where doctors look things up. Anyone can search it, and almost nobody does.

I typed in the one thing that kept coming up in the research on clearing fat out of a liver. Silymarin. The active compound in milk thistle.

I was expecting a handful of small, shaky studies. That is usually what you find when you check a supplement properly. What I actually found was 30 years of work on it, including reviews that pool dozens of trials together.

Here are the 5 most convincing ones I found, and what each one actually concluded. I have put the conclusions in plain English, and the full titles and sources are printed at the bottom of this page so you can look them up yourself.

The Most Convincing Research I Found

5 studies on silymarin and fatty liver, with the conclusion of each one underneath it.

Silymarin in fatty liver: a review of the trials, 20241

Conclusion:Silymarin helps the body handle energy better, cuts down the damage being done to the liver, and improves what the liver tissue itself looks like in people with fatty liver.

Plant compounds tested in fatty liver, 20222

Conclusion:Silymarin reduces liver enzymes.

Silymarin and liver enzymes in chronic liver disease, 20253

Conclusion:Silymarin lowers ALT and AST, and gets more people's ALT all the way back into the normal range than standard treatment does. It worked best of all in people whose liver problem was fatty liver.

8 weeks of milk thistle before weight loss surgery, 20224

Conclusion:8 weeks of milk thistle improved the fatty liver grading on their scans and brought their liver enzymes down, with no side effects.

Silymarin alongside diet and exercise, 20255

Conclusion:Silymarin combined with diet and exercise changes is a safe and effective way to bring liver enzyme levels down, and to get them back to normal, in people with fatty liver.

Number 4 is the one that stopped me. Not 2 years. 8 weeks.

And then read number 5 again, because it is the whole reason I am writing this.

I had already done the diet. I had already done the walking. I had already lost the stone and a half. I had done the entire half of the job my doctor gave me, and I had done it properly for 6 months.

I was one ingredient away from the thing in that study, and nobody had ever mentioned it to me.

And Then I Noticed What They Actually Gave People

This is the part I nearly scrolled past, and it turned out to matter more than anything else on this page.

Go back and look at what was in the capsules in those trials. Most of them did not use milk thistle powder. They used silymarin standardised to 80%. The strong, measured extract, at a strength somebody had actually checked.

That is not a detail. That is the whole study. When a trial says silymarin worked, it is telling you that that worked. It says nothing at all about a tub of ground up seed.

And one of the trials went the other way. Instead of using the standardised extract, it used big doses of ordinary silymarin to try and make up the difference.

It gave people stomach and gut problems.

Which killed the idea I had already had, sat there at my kitchen table, thinking I was being clever. If the cheap one is weak, just take a handful of them.

No. You cannot swallow your way out of a weak extract. You either get the strength in the capsule or you do not.

Now, I want to be straight with you about what this is and what it is not, because I have spent 15 years catching other people being sloppy with exactly this.

These studies are on silymarin. They are not studies on any particular bottle, and no supplement company gets to borrow them and claim the results as its own. Some of them are small. One of them had no placebo group. And a review of trials is only ever as good as the trials that went into it.

But this is a plant compound with 30 years of research behind it, sitting in a chemist aisle, and not one person in my care had ever said the word to me. Not the GP. Not the nurse. Nobody.

So I went to buy some. And that is where I hit the next problem.

You Are Buying Plant Weight, Not A Dose

Milk thistle came up constantly in the literature. It has been studied in liver disease for decades. It is the single most researched botanical there is for this. Which made my eight useless weeks on a chemist tub even harder to explain, so I went back and checked why, and the answer was in the small print on the back.

Milk thistle the plant is not the active substance. The active fraction is a group of compounds called silymarin, and it makes up only a part of the seed.

Which means a tub proudly announcing 1,000mg of milk thistle is telling you almost nothing. It is telling you how much plant went in. It is not telling you how much silymarin came out.

You are not buying a dose. You are buying a lottery ticket.

What The Label Actually Has To Tell You

The one number that separates a dose from a lottery ticket

Typical high street tub, standardisation statedoften none
Where cheaper extracts commonly sit30–40%
The standard the clinical literature is built on80%
Silymarin in a 1,000mg tub at 4% seed powder40mg
Silymarin in 300mg of extract standardised to 80%240mg

Worth being straight about the limits of this. Standardisation tells you how much of the active stuff is in the capsule. On its own it does not promise you a result, and most of the silymarin research looks at blood markers rather than at how people feel. It is the one thing on a label you can actually check before you buy, which is why I started there.

Standardisation is the whole game. A product standardised to 80% silymarin is guaranteeing the active content in every capsule. My chemist tub did not state a percentage anywhere on it. I checked three others in the same aisle. Two of them did not either.

Most liver supplements are not weak because the plant does not work. They are weak because you are buying the plant instead of the compound.

He stopped reading the front of the tub and started reading only the back.
He stopped reading the front of the tub and started reading only the back.Photo: The Health Examiner

The Formula

Why This One Was Built Differently

I was sceptical to start with. After 15 years of taking apart supplement companies I have learned to be. But three things about Uvera caught my attention.

First, it was not one of those 24 ingredient liver complexes. It is 6 things, and the main one is in there at a real dose. Standardised to 80% silymarin. 300mg of milk thistle extract giving 240mg of actual active silymarin in every capsule, and that number is printed on the label because it is the whole point of the product. But the silymarin was not the reason I bought it.

Second, the ingredients work in two directions at once. Silymarin is a protector. It stabilises liver cell membranes and works as an antioxidant inside the cell, which matters a lot when those cells are inflamed and leaking enzymes into your blood. It protects the cells doing the work. But protecting the plant does not clear the yard. For that you need fat to physically move out of the liver, and the compounds involved in that are called lipotropics. Inositol and L-methionine are lipotropics. They sit right next to the silymarin on this label.

Third, everything is printed in milligrams. No proprietary blend, which is the phrase that means they will not tell you.

What Is Actually Inside

Per capsule · every amount printed · no proprietary blend

Milk thistle extract, standardised to 80% silymarin300mg
of which active silymarin240mg
Inositol, involved in moving fat out of liver cells200mg
Pueraria68mg
L-methionine, a methyl donor that helps package fat for export10mg
Vitamin C10mg
Turmeric4mg

One half of the formula helps shift what is already stored. The other half protects the tissue while it happens. Clear the yard, and protect the plant while you clear it.

6 ingredients, every one of them printed in milligrams, and the one that does the work is over the line rather than under it. That is the difference. The products I had tried before this one had 4 times the ingredient list and a fraction of the dose, and the reason none of them moved my numbers is that a long list on the back of a tub is not the same thing as a dose in the capsule.

What readers report

“I'd tried the cheap chemist milk thistle and felt nothing — turns out it was only 30% silymarin. The 80% in Uvera is a completely different story. I actually feel a difference.”

Marcus T., 41 · ManchesterVerified

“Went for Uvera because the 80% silymarin actually matches what the research studies use. Two weeks in the afternoon crash softened. By the second bottle I stopped feeling that heavy, sluggish thing after meals.”

Ravi P., 52 · BirminghamVerified

“I'm four months in and just had my bloods redone. My liver enzymes are back to normal. My GP actually said ‘whatever you're doing, keep doing it.’”

Charlotte W., 39 · CardiffVerified

Uvera is made in the UK and sold direct. Stock moves in batches, so availability changes.

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My Own Experiment

I Tracked Everything. Here Is What Happened.

Being a journalist means questioning everything, hope included. So I treated it like any other investigation. Full bloods beforehand. A written log every day. My starting point was ALT 112 and AST 89, yellow in the whites of my eyes, a stomach that bloated after anything, and an afternoon I lost every single day.

Days 1 to 6: nothing at all

Nothing. I want to be honest about that, because anyone who tells you they felt something on day two is selling you something. I almost stopped.

Week 2

The half past two thing stopped. I noticed it because I got to five o'clock one Thursday still working and realised I had not had the afternoon collapse.

Week 3

My wife noticed before I did. I ate a full dinner and did not undo the top button of my trousers afterwards. That tight, swollen, pushing feeling after an ordinary meal had gone, and I had not registered it going.

Week 5

I slept through. Not once, consistently. The four in the morning thing stopped.

Week 7: the first real evidence

Bloods, done privately because I did not want to wait. ALT 71. AST 55. Thirty-two points in seven weeks, after nine points in six months. I read it twice and then I rang my wife from the car park, which is not a thing I do.

Week 7. Thirty-six points, after nine points in six months.
Week 7. Thirty-six points, after nine points in six months.Photo: The Health Examiner

Week 10

My wife told me the yellow had gone out of my eyes. I went and stood in front of the bathroom mirror, the same one, and she was right. I had been checking it every morning for months without admitting that was what I was doing.

Month 5: the recheck

ALT 28. AST 24. Both inside range. Not borderline. Inside.

"Well, that is a completely different picture," my GP said. "Whatever you are doing, keep doing it."

The ultrasound six weeks later described my liver as unremarkable. Unremarkable. I have never been so pleased to be called anything.

I am trained to follow evidence rather than feeling. But the evidence that actually landed was not on the printout. It was standing at the bottom of a hill in the Peaks in August with my son, not out of breath, having a conversation. I had spent two years being the one who waited at the car.

Real People, Real Numbers

I Am Not The Only One

I wrote about this once, briefly, in a column. I was not expecting much. I got more post than I have had for any piece in 15 years, and the striking thing was not the volume. It was how similar the letters were.

The same six months. The same nine points. The same sentence about coming back for a recheck. The same feeling of having done everything correctly and been told it was not enough, without ever being told what else to do. The most common line, in various forms, was this one.

"I thought I was the only person it was not working for."

You are not. That is genuinely the main thing I want to say to anyone reading this with a letter like mine in a drawer somewhere.

4.8
★★★★★

Average rating across 11,690 reviews on the official site. Leave the rating field blank to hide this block.

From the Mailbag

A selection of the letters that came in after the column ran.

"I've always been a wine person. Not an alcoholic in any sense, but two or three glasses most evenings after work. Last year my bloodwork came back with raised liver enzymes and the GP said we need to keep an eye on this. That frightened me, I'm not even 40 yet. I discovered milk thistle needs to be 80% silymarin to properly work; most of the cheap ones on the chemist shelf are only 30 to 40%. I'm four months in and just had my bloods redone. My liver enzymes are back to normal."

Charlotte W., 39 · CardiffVerified

"My beer belly wasn't just beer, turned out my liver was crying for help. Bloated belly, wiped out by 2pm every afternoon, ridges on my nails I'd put down to getting older. Started this after reading it has to be standardised to 80% to actually do anything. Around day 12 I woke up and my stomach felt properly different. By week three my energy was back, I wasn't dragging myself through the afternoon."

Steven H., 47 · EdinburghVerified

"Right, this is embarrassing to admit but if it helps one person it's worth it. The wind was completely out of control, all day, every day. My belly would bloat so badly by lunchtime that I kept a spare pair of trousers with an elastic waist in the car. Constantly knackered, asleep on the sofa by 7pm. Started because the 80% silymarin looked legitimate. First week, nothing. Second week the wind eased off. By week three my stomach wasn't ballooning after lunch."

Andrew P., 44 · NewcastleVerified

"I take it with my morning tea and forget about it. The bloating had become just me, turns out it wasn't me at all, it was my liver. A month in and my trousers are looser round the middle without changing a thing about my diet. Sleep is deeper too. Two bottles in and I don't feel that heavy weight in my middle anymore. Wish I'd started sooner, but there you go."

Fiona M., 43 · GlasgowVerified

"I was bloated and puffy by every afternoon and just put it down to getting older. Two weeks on it and the puffiness is noticeably down, and my 3pm slump basically disappeared."

Dana R., 53 · BristolVerified
Reader with Uvera
Reader with Uvera
Two of the readers who wrote in.Reader photos
11,690Reviews on the official site
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4.6 / 5

Gareth's verdict

I am not saying this is a treatment. It is a food supplement. I am not saying it replaces losing weight or stopping drinking. It absolutely does not. I did both and I would tell you to do both.

What I am saying is that stopping the cause was never going to clear what was already stored, nobody told me that, and the six months I lost to not knowing it is the reason I have written 3,000 words about my own blood tests.

Marked down for one thing: it is not fast. Nothing happened in week one, and my numbers were not in range until month five. And you need bloods to know whether it is working, which means asking your GP or paying for a private test. The thing that proves it works is the thing most people will not do.

Where to Get It

Where Can I Get Uvera?

It is made in the UK to GMP standards and sold direct rather than through the chemist, which is the only reason I had not come across it in that aisle. Having now looked at how they manufacture and what they publish on the label, that route makes sense to me. The margin that would have gone to a retailer went into the extract instead.

Uvera

Uvera

Made in the UK · 30 capsules · 90 day guarantee

One bottle is 30 capsules, which is one month, at £29.99.

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Do Not Buy One Bottle

My enzymes did not move at seven weeks by accident, and they were not in range until month five. This is a liver. It works on a liver's timescale, not on how patient you feel. One bottle tells you nothing. If you are going to do this, do three months minimum, and the multi-bottle bundle brings it down to around 39p a day, which is less than the coffee I used to drink while feeling sorry for myself.

There is a subscription option as well, which I moved onto after the second month. It takes 20% off every order and it removes the thing that quietly ruins this for people, which is running out for four days and never quite restarting.

And Use The Guarantee Properly

There is a 90-day money back guarantee. Ninety days is not a returns window on this product. It is roughly the length of a fair trial. Get your bloods done before you start, take it properly for three months, get them done again, and then decide with a number in front of you rather than a feeling.

That is what I would have wanted somebody to tell me in the car park.

One Last Thing

Fatty liver is one of very few serious diagnoses where the story can still go the other way. Fat in the liver can clear. Early scarring can improve. The organ is genuinely capable of repairing itself in a way that hearts and kidneys are not.

But that window does not stay open forever, and the cruel part of the design is that it does not hurt while it is closing. There is no warning shot. How bad you feel does not match how bad it is getting, which is why so many people get told at 45 that it is nothing to worry about and get told something very different at 60.

My father's liver never spoke up until the year it stopped compensating, and it took him at 52. Mine spoke up in a bathroom mirror at 49, and that turned out to be early enough.

I had six months of doing everything right and getting nine points, and I very nearly concluded from that that nothing would work.

If your bloodwork is telling you what mine told me, do not file it away for six months. Twelve months of I will deal with it later is how every one of those midnight stories started.

You were told to shut the gates. Nobody told you about clearing the yard.

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References

  1. Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis. PubMed, National Library of Medicine. pubmed.ncbi.nlm.nih.gov/38579127/
  2. Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis. PubMed, National Library of Medicine. pubmed.ncbi.nlm.nih.gov/36159792/
  3. Impact of Silymarin Supplementation on Liver Function and Enzyme Profiles in Diverse Chronic Liver Disease Etiologies. PubMed, National Library of Medicine. pubmed.ncbi.nlm.nih.gov/39850184/
  4. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery. PubMed, National Library of Medicine. pubmed.ncbi.nlm.nih.gov/35651885/
  5. Effectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study. PubMed Central, National Library of Medicine. pmc.ncbi.nlm.nih.gov/articles/PMC13082349/

This is an advertisement and not an actual news article. The account described is a sponsored feature.

The Health Examiner

Gareth Vaughan is a health correspondent writing in a sponsored feature for Uvera.

Food supplement. Not a medicine and not intended to diagnose, treat, cure or prevent any disease. Do not use as a substitute for a varied diet and healthy lifestyle. If you have a liver condition, speak to your GP.